Celsius Therapeutics to Present Preclinical Data on Anti-TREM1 Antibody at 18th Congress of ECCO – Inflammatory Bowel Diseases

CAMBRIDGE, Mass.—February 27, 2023—Celsius Therapeutics, a biotechnology company pioneering new precision medicines for patients with cancer and inflammatory disease by harnessing the power of single-cell RNA sequencing and human biology at scale, today announced that new data on CEL383, a potential first-in-class anti-TREM1 antibody for the treatment of inflammatory bowel disease (IBD), has been selected for a digital oral presentation at the 18th Congress of ECCO – Inflammatory Bowel Diseases, hosted by the European Crohn’s and Colitis Organisation from March 1-4, 2023, in Copenhagen, Denmark.

Oral Presentation Details

Title: Single cell RNA sequencing of Ulcerative Colitis and Crohn’s Disease tissue samples informs the selection of Triggering Receptors Expressed on Myeloid Cells 1 (TREM1) as a target for the treatment of Inflammatory Bowel Diseases
Presenter: Sarah Grant, M.D., Chief Medical Officer, Celsius Therapeutics
Session Title/Type: DOP Session 1: Basic Science in IBD 1, Presentation # DOP02
Date & Time: Friday, March 3, 2023, 17:36 – 17:42 CEST
Session Hall: Room C-M0

“We are thrilled to present insights identified through our SCOPE platform (Single Cell Observations for Precision Effect) that point to an important role for TREM1 in inflammatory bowel disease and led to the initiation of our CEL383 program at ECCO 2023,” said Tariq Kassum, M.D., President and CEO of Celsius. “We anticipate filing an investigational new drug application for CEL383 with the U.S. Food and Drug Administration and commencing a Phase 1 clinical study in the first half of this year.”

About CEL383
CEL383 is Celsius’ first clinical candidate. TREM1, a myeloid target with a central role in IBD, was identified through single cell analysis of hundreds of clinical samples using machine learning algorithms via the company’s SCOPE platform. Through this approach, Celsius was able to identify and deeply characterize pathogenic cell types that are tightly associated with inflammation, including in the context of resistance to anti-TNFα therapies, and has defined a series of targets modulating behavior of these cell subtypes. TREM1, an amplifier of mucosal inflammation, is the first of these targets. Celsius plans to initiate a Phase 1 clinical study with CEL383 in the first half of 2023.

About Celsius Therapeutics
Celsius Therapeutics is a biotechnology company developing novel precision medicines in inflammatory disease and cancer by harnessing the power of single cell RNA sequencing and human biology at scale. The company’s first therapeutic candidate is an anti-TREM1 antibody for the treatment of inflammatory bowel disease, and the company has multiple ongoing drug discovery programs in oncology. Celsius is based in Cambridge, Mass. For more information, please visit https://celsiustx.com/, or follow us on LinkedIn or Twitter.

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