TRANSLATING SINGLE CELL INSIGHTS INTO NOVEL PRECISION THERAPIES

We interrogate multiple diseases through in-depth single cell RNA-sequencing of longitudinally collected tissue samples from patients undergoing various treatments. Our unique approach allows us to identify molecular mechanisms relevant to human biology and to identify genes that causally contribute to disease. We then rapidly turn these insights into drug discovery efforts aimed at developing therapeutics for biomarker-defined patient populations. 


Therapeutic AreaCurrent Disease Indication FocusClinical ScreensDrug Discovery Focus
AutoimmuneInflammatory Bowel Disease>5 independent screens across different IBD settingsInterrogating mechanistic subsets of disease and treatment response to identify novel drug targets for polygenic IBD
OncologyOncology primary and secondary (or acquired) treatment resistance>5 independent screens across different tumor typesLeveraging tissue, genotype, and mechanism-centric approaches to identify novel drug targets for cancers refractory to current treatments, including checkpoint therapies