Single Cell Genomics on an industrial scale

We are harnessing the power of single-cell RNA sequencing to markedly improve human health. Our objective is to understand how small cell populations and dynamics drive disease in order to develop breakthrough therapies for patients with difficult-to-treat diseases.

Our approach not only has deep implications for treatments but also helps identify the best choices for drug combinations and how to match effective medicines with the right patients.

Our product engine is built on a rigorous multi-step approach:

Celsius has unique combination of capabilities to reveal new targeted treatment opportunities through SCG

Samples

Right types and number of intact human tissue samples through strategic screens

Industrialized SCG

High-throughput capability to generate reproducible, quality-controlled data

Computation

Robust computational and machine learning capabilities to integrate, interrogate, and interpret complex datasets

Deep Biology and Drug Discovery

Experienced gene and drug hunters focused on rapid validation of novel drug targets for specifically defined patient populations

Celsius approach can rapidly identify disease drivers and patient subsets

Obtain samples

Intact human tissue samples:
  • Large patient cohorts
  • Longitudinal collection of multiple samples / patient
  • Deep clinical annotation

Perform single cell RNA-seq

Identification of:
  • (Rare) cell types
  • Disease-altered cellular states
  • Cell-cell interactions
  • Molecularly defined patient subsets

Generate insights rapidly

Accelerated hypothesis generation:
  • Integration of orthogonal datasets
  • Machine Learning techniques
  • Streamlined target validation using Functional Genomics

    Industrialized SCG

    [wording open to modification]

    High-throughput capability to generate reproducible, quality-controlled data

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    Computational Biology & Machine Learning

    [wording open to modification]

    Robust computational and machine learning capabilities to integrate, interrogate, and interpret complex datasets

    Our product engine includes sophisticated data-driven tools and computational methods that allow us to prioritize which cells and genes matter in complex diseases.

    Deep Biology & Drug Discovery

    [wording open to modification]

    Experienced gene and drug hunters focused on rapid validation of novel drug targets for specifically defined patient populations

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